As one of the city's best-preserved art-deco buildings, the villa boasts an interior designed by the renowned Ateliers d'Art De Coene, characterised by wood-panelled walls, stained-glass windows and parquet flooring.
For the inaugural exhibition, called Hôtel Maniera, the design gallery commissioned 15 new collectible furniture pieces from its roster of contemporary artists and architects.
They can be found in every room on the ground floor of the historic house, even the lavatory, while some of the gallery's previous commissions are presented in the rose garden.
"It was a very ambitious opening," said Amaryllis Jacobs, who founded the gallery with partner Kwinten Lavigne nearly a decade ago.
"We invited all of our artists and architects if they wanted to do something, and a lot of them said yes," she told Dezeen. "This is the way the Maniera family furnishes a house."
One of the most striking pieces of show is an ambigious work by Austrian artist Lukas Gchwandtner, titled Lazy Pillows.
Located in the dining room, it consists of a steel platform topped with feather-filled cushions, which could be interpreted as a table, a bed or a sofa.
The living room is meanwhile furnished entirely with works by Nata Janberidze and Keti Toloraia of Georgian studio Rooms, including their blocky Historic Bench and the monumental oak Lovers sofa.
Other works on show include a winding steel and rope floor lamp by Belgian sculptor Valérie Mannaerts and cone-shaped copper and brass lights by architecture studio Piovenefabi.
Hôtel Danckaert is one of several residential spaces that Maniera has occupied over the years.
When the gallery first launched in 2014, it was in Jacobs and Lavigne's own apartment. More recently, they have hosted pop-up exhibitions in houses that include the brutalist-style Van Wassenhove House near Ghent.
It was this that led the gallerists to seek out an architect-designed villa.
"We wanted to move out of the city centre, but we knew we had to find a special house," said Jacobs.
They felt an older building would make a more striking setting to display contemporary furniture, creating opportunites for surprising juxtapositions.
"It's such a beautiful house; all these pieces stand out here and become so much more beautiful," Jacobs said.
"A lot of visitors also say that our pieces make the house shine," she added.
The photography is by Jeroen Verrecht.
Hôtel Maniera is on show at from 4 March to 6 May 2023. See Dezeen Events Guide for an up-to-date list of architecture and design events taking place around the world.