The studio's background in architecture is evident in the one-shot sequence, which creates a cinematic impression of a city facing destruction.
Combining references from across film, television and video games, the fast-paced video sees the city under siege through bank robbery, biological destruction and fire-breathing monsters.
Factory Fifteen co-founder Paul Nicholls describes it as "a CGI extravaganza".
"We proposed an idea where the world unexpectedly freezes, and the camera goes on a journey where around every corner there is a different moment in epic cinema," he said.
The video is a showcase of Spitfire Audio's Albion Colossus library, a collection of orchestral sounds created with action movies in mind.
The drama begins with a view of a man falling from a skyscraper resembling New York's Empire State Building.
Time freezes just before he hits the ground. It is at this point that the camera begins to move and new scenes unfold, each revealing a different dimension to the action.
One scene shows buildings and streetscapes overtaken by nature in homage to the post-apocalyptic TV series The Last of Us, while the final scene references movies like Godzilla, where monsters wreak havoc across the city.
As time is frozen, the soundtrack was vital in bringing the scenes to life. "The music brings drama and tension," said Nicholls.
Factory Fifteen's work often features striking visions of buildings and cityscapes.
The studio directed the BBC's BAFTA-winning Tokyo 2020 promotion video, which wove a story of British athletes in the streetscapes of Japan's capital.
The Colossus video was produced in a similar way.
"It's to do with the clever camera transitions," revealed Nicholls. "It feels like it's one really big space but it's actually one very strange assembly of lots of different spaces."
"Over the course of the animation, they get smaller and smaller. You're not creating miniature sets, but you're putting things abnormally close together to produce the conceptual effects."
Nicholls and former classmates Jonathan Gales and Kibwe Tavares co-founded Factory Fifteen in 2011 after studying architecture together at The Bartlett School of Architecture in London.
Nicholls described Colossus as "a homage to our past with a more lighthearted tone".
The video release follows the tragic death of Gales, who was hit by a suspected drunk driver in downtown Los Angeles in late 2022.
Since then, Factory Fifteen has rebranded itself with a new logo, website and showreel, and relocated to a self-designed studio in southeast London.
"I'm hoping Jono would be proud of the new direction," said Nicholls.