The project, which has been submitted for a development application, would see ten buildings built on a 7.6-acre site in downtown Los Angeles between Fourth Street and Central Avenue.
If approved, construction would begin in 2024.
Los Angeles-based architecture office Studio One Eleven has designed a mixed-use development for the site that would range in height from two to 42 storeys.
Along with 1,521 residential units and a 68-room hotel, plans for Fourth and Central include 401,000 square feet (37,000 metres) of office space and 93,000 square feet (8,640 square metres) for retail and restaurant use.
Adjaye designed two buildings for the project. The founder of Adjaye Associates has previously designed a pink concrete shop for fashion retailer The Webster in Los Angeles, but this would be his first ground-up project in the city.
"Working with David Adjaye and his team, we've designed an open, street-level plan that incrementally connects with the neighbourhood, providing diverse buildings, a rich mix of uses, and abundant green space – all human-scaled and accessible," said Studio One Eleven founder Alan Pullman.
Studio One Eleven plans to make the development walkable and cycle-friendly.
"Fourth and Central provides an unmatched opportunity to leverage major transit improvements in a way that responsibly uplifts the community with increased housing and commercial opportunities," he added.
Last year the Los Angeles County Metropolitan Transportation Authority (Metro) revealed a 30-year plan to improve public transport across the city, including plans to add more rail and metro stations to the downtown area.
Continuum Partners also said it intended to make sure the residential units would be priced for a range of incomes, in response to the city's escalating homelessness crisis fuelled by high rents and lack of affordable homes.
"We're encouraged that community-minded developers like Continuum Partners are looking to invest in responsible development that creates living wage jobs and housing opportunities for a mixture of income levels, said Weingart Center CEO Kevin Murray. The Weingart Center is a non-profit that provides services for homeless people in Los Angeles.
In response to the crisis, Leher Architects has been working with the City on a trio of village-style sites filled with cabin-style prefabricated shelters and amenities for homeless people in Los Angeles.
Images courtesy of Studio One Eleven and Adjaye Associates.